Experts release predictions for Bills vs. Jaguars for AFC Wild Card Weekend

The Buffalo Bills travel to Jacksonville this Sunday AFC wild card matchup against the No. 3 seed Jaguars. While the Bills (12-5) have reached the postseason for the seventh straight year, they come in as the No. 6 seed after their five-year reign atop the AFC East was snapped by the New England Patriots.

Buffalo’s defense enters the playoffs with significant concerns, especially on special teams after veteran kicker’s quad injury Matt Prater in the final of the regular season. The Jaguars (13-4), winners of eight straight games, enter as one of the league’s hottest teams under first-year head coach Liam Cohen. Jacksonville’s resurgent offense led by Trevor Lawrence and the rushing star Travis Etiennewill look to take advantage of a Bills unit that has struggled against the run all season.

The contrast between Buffalo’s postseason experience and Jacksonville’s late-season dynamism prompted analysts to immediately reevaluate the starting lineup. The new simulations focus on whether Josh Allen able to overcome the Jaguars’ physical pass rush while Buffalo’s shorthanded defense tries to slow down Jacksonville’s high-scoring offense.

The results of these simulations were compared with updated betting odds to construct the data-driven Bills-Jaguars preview below.

Banks vs. Betting Preview Jaguars

Explore the interactive widget below for the latest spreads, total and money odds and odds for the Bills-Jaguars game at EverBank Stadium.

This prediction and best bet for Sunday’s NFL game between the Bills and Jaguars comes from Dimers.comtrusted source for sports betting predictions.

Check out all the important details on today’s game as well as the best odds from the best bookmakers in the country.

Game details

Bills vs. Key Game Info Jaguars, including where the game is and when it starts.

• Teams: Buffalo Bills vs. Jacksonville Jaguars
• data: Sunday, January 11, 2026
• Excavations: 1:00 PM EST
• Location: EverBank Stadium
• NFL standings: Current NFL Division Standings
• NFL Injuries: Check out the latest updates on the NFL’s official injury report

Courses

Bills-Jaguars NFL Key Market Odds.

• Spreads: Bills -1.5 (-106), Jaguars +1.5 (-110)
• Moneylines: Bills -118, Jaguars +102
• Total: Over 51.5 (-110/-105)

The odds and lines shown in this article are the best available from selected sports betting sites at the time of publication and are subject to change.

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Expert Prediction: Bills Vs. Jaguars

Using state-of-the-art data analysis and advanced algorithms, Dimers’ experts ran 10,000 simulations of Sunday’s Banknotes vs. Jaguars matches.

According to Dimers’ independent predictive analytics model, The Bills are more likely to beat the Jaguars at EverBank Stadium. This prediction is based on a model that gives the Bills a 56% chance of winning the game.

Furthermore, Dimers predicts that the bookies got it right, with the Bills and Jaguars each having a 50% chance of covering the spread, while an over/under total of 51.5 points has a 54% chance of staying under.

These predictions and probabilities are accurate at the time of publication but are subject to change.

Best Bet Bill vs. Jaguars

Our top tip for Sunday’s Bills vs. The Jaguars are on the line Less than 51.5 points (-105).

This expert betting advice is based on world-class modeling and valuable betting intelligence to help you invest smarter.

Score Prediction for Bills vs. Jaguars

Dimers’ projected final score for Sunday’s Buffalo vs. Jacksonville beat the Bills 25-24.

This expert prediction is based on each team’s average score after 10,000 game simulations and offers insight into the potential outcome.

NFL Player Supporters: Sunday

NFL player prop bets are a nice way to bet on Sunday’s game without necessarily betting on the outcome.

This article contains the most likely first and all-time touchdown scorers for the Bills and Jaguars, as well as projected player statistics.

Buffalo Bills

First Touchdown Scorer Predictions

• James Cook: 12.1% probability
• Josh Allen: 9.4% probability
• Ty Johnson: 4.5% probability

Anytime landing predictions

• James Cook: 59.6% probability
• Josh Allen: 50.7% probability.
• Ty Johnson: 28.9% probability

Predicted Box Score Leaders

• QB Passing Yards: Josh Allen229 yards
• Receiving Yards: Khalil Shakir50 yards
• Rushing yards: James Cook90 yards

Jacksonville Jaguars

First Touchdown Scorer Predictions

• Travis Etienne: 12.8% probability
• Trevor Lawrence: 7.7% probability
• Jakobi Meyers: 5.6% probability.

Anytime landing predictions

• Travis Etienne: 54.8% probability
• Trevor Lawrence: 38.1% probability
• Jakobi Meyers: 29.3% probability

Predicted Box Score Leaders

• QB Passing Yards: Trevor Lawrence235 yards
• Receiving Yards: Jakob Meyers57 yards
• Rushing yards: Travis Etienne66 yards

NFL Week 19: Bills vs. Jaguars

Get ready for Sunday’s action between the Bills and Jaguars in the wild card round NFL season at EverBank Stadium, scheduled to begin at 1 p.m. EST. Please note that all NFL best bets and NFL predictions in this article are based on 10,000 simulations based on Bills vs. Jaguars and are correct at the time of publication to help you make better betting decisions at online bookmakers.

When choosing online betting, remember to bet responsibly and get the latest and most accurate information from reliable sources.

If you or a loved one have questions or need to speak with a gambling professional, call 1-800-GAMBLER or visit 1800gambler.net for more information.