The Buffalo Bills will travel to Empower Field at Mile High to face the Denver Broncos in the AFC Divisional Round on Saturday. Kickoff is scheduled for 4:30 PM EST on CBS.
Uncertainty surrounding Buffalo’s depleted receiving corps has become a major storyline heading into this high-stakes matchup. Third-year WR Tyrell Shavers, who finished second on the team in receiving yards, remains out after tearing his ACL during the Bills’ Wild Card win. Head coach Sean McDermott confirmed the news on Tuesday, leaving Buffalo with only three healthy receivers on the active roster.
Rookie Keon Coleman and veteran Khalil Shakir are expected to carry the load unless reinforcements are added. The Bills are also monitoring QB Josh Allen, whose head, arm and leg injuries worsened in Jacksonville.
Denver’s defense is also seeing changes. Linebacker Dre Greenlaw, who has been sidelined since Week 16 with a hamstring injury, returned to practice on Tuesday. Head coach Sean Payton expressed optimism, noting, “It’s good to have a healthy Dre Greenlaw.”
This update prompted analysts to reevaluate your Bills vs. Broncos and player stat projections using new simulations that factored into Buffalo’s extensive injury list. The results were compared with the updated bookmaker odds to compile the data-driven preview below.
Bills vs. Betting Preview Broncos
Explore the interactive widget below to see current betting odds and spread, over/under and moneyline odds for the Bills-Broncos game at Empower Field at Mile High.
This prediction and best bet for Saturday’s NFL game between the Bills and the Broncos is from Dimers.comthe leader in sports betting predictions.
Check out all the important details on today’s game as well as the best odds from the best bookmakers in the country.
Game details
Key information you need ahead of Bills vs. NFL Broncos.
- Teams: Buffalo Bills vs. Denver Broncos
- data: Saturday, January 17, 2026
- Excavations: 4:30 PM EST
- Location: Empower Field at Mile High
- NFL standings: Current NFL Division Standings
- NFL Injuries: Check out the latest updates on the NFL’s official injury report
Courses
Odds on key markets in the Bills-Broncos NFL battle.
- Spreads: Bills +1 (-115), Broncos -1 (-105)
- Moneylines: Bills -108, Broncos -108
- Total: Over/Under 46.5 (-108/-110)
The odds and lines shown in this article are the best available from selected sports betting sites at the time of publication and are subject to change.
Expert Prediction: Bills vs. Broncos
Using trusted data analysis and computing power, Dimers experts ran 10,000 simulations of Saturday’s Bills vs. Broncos game.
According to Dimers’ independent predictive analytics model, The Broncos are more likely to beat the Bills at Empower Field at Mile High. This prediction is based on a model that gives the Broncos a 56% chance of winning the game.
In addition, Dimers predicts that the Broncos (-1) have a 52% chance of covering the spread, while an over/under total of 46.5 points is considered an equal chance of hitting 50-50.
As always, these predictions and probabilities are correct at the time of publication, but are subject to change.
Best bet Bills vs. Broncos
Our best pick for Saturday’s Bills vs. The Broncos are betting on Broncos moneyline (-108).
This expert betting advice is formulated through comprehensive modeling and valuable betting insights to help you invest smarter.
Score Prediction for Bills vs. Broncos
Dimers’ projected final score for Saturday’s Buffalo vs. Denver beat the Broncos 23-22.
This expert prediction is based on each team’s average score after 10,000 game simulations and offers insight into the potential outcome.
NFL Player Supporters: Saturday
NFL tipsters are an exciting way to bet on Saturday’s game without necessarily betting on the outcome.
This article contains the most likely first and all-time touchdown scorers for the Bills and Broncos, as well as projected player statistics.
Buffalo Bills
First Touchdown Scorer Predictions
- James Cook: 12.2% probability
- Josh Allen: 9.9% probability
- Khalil Shakir: 4.7% probability
Anytime landing predictions
- James Cook: 57.3% probability.
- Josh Allen: 49.9% probability
- Khalil Shakir: 28.0% probability
Predicted Box Score Leaders
- QB Passing Yards: Josh Allen216 yards
- Receiving Yards: Khalil Shakir54 yards
- Rushing yards: James Cook84 yards
Denver Broncos
First Touchdown Scorer Predictions
- RJ Harvey: 11.8% probability
- Courtland Sutton: 6.6% probability.
- Jaleel McLaughlin: 4.1% chance
Anytime landing predictions
- RJ Harvey: 53.4% ​​probability
- Courtland Sutton: 34.8% probability
- Jaleel McLaughlin: 23.3% probability
Predicted Box Score Leaders
- QB Passing Yards: Bo Nix219 yards
- Receiving Yards: Courtland Sutton54 yards
- Rushing yards: RJ Harvey52 yards
NFL Week 20: Bills vs. Broncos
Get ready for Saturday’s divisional round matchup between the Bills and the Broncos NFL season at Empower Field at Mile High, set to begin at 4:30 p.m. EST. Please note that all NFL predictions and NFL best bets on this page are derived from 10,000 data-driven simulations of the Bills vs. Broncos and are correct at time of publication. They are intended to help you make better decisions when placing bets at online bookmakers.
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